IGF-DES

Description

IGF-1 DES (1-3), also known as Des(1-3)IGF-1, is a truncated, high-potency variant of insulin-like growth factor 1, lacking the first three N-terminal amino acids of the full-length protein.

In laboratory research, IGF-1 DES is examined for its reduced binding affinity to IGF-binding proteins (IGFBPs) relative to full-length IGF-1, a structural feature studied for producing more localized, higher-potency receptor signaling in experimental tissue models.

Researchers studying IGF-1 DES focus on its use as a tool for isolating direct IGF-1 receptor activation from the regulatory influence of binding proteins, offering a cleaner experimental model for studying growth factor receptor signaling kinetics.

Its localized, high-potency activity profile has made IGF-1 DES a frequently referenced compound in comparative growth factor research examining structure-function relationships within the IGF family.

IGF-1 DES is supplied strictly for laboratory research into growth factor receptor signaling and comparative IGF pathway research.