Description
PNC-27 (supplied here at 10mg) is a synthetic peptide derived from the MDM2-binding domain of the p53 tumor suppressor protein, studied in cancer cell biology research for its membrane-targeting activity.
In laboratory research, PNC-27 is examined for its proposed mechanism of forming pores in cancer cell membranes by exploiting elevated HDM-2 (MDM2) expression at the surface of transformed cells, a feature reportedly less present in non-cancerous cells.
Researchers studying PNC-27 focus on its selective cytolytic activity as a model for p53-pathway-independent approaches to targeting malignant cells, distinguishing it from conventional apoptosis-inducing compounds.
The larger 10mg quantity supports researchers running extended cell-culture protocols or comparative dose-response study designs requiring a greater available reagent volume.
PNC-27 is supplied strictly for laboratory research into p53 pathway biology, membrane-targeting peptides, and cancer cell biology.
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